The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy

• Κύριοι συγγραφείς: Rüb, Udo (Συγγραφέας), Vonsattel, Jean Paul G. (Συγγραφέας), Heinsen, Helmut (Συγγραφέας), Korf, Horst-Werner (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Έκδοση: 1st ed. 2015.
• Σειρά: Advances in Anatomy, Embryology and Cell Biology, 217
• Θέματα: Medicine.; Human genetics.; Neurosciences.; Pathology.; Biomedicine.; Human Genetics.

This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldw...

Πίνακας περιεχομένων:

• 1. Introduction
• 2. The neuropathological grading of Huntington disease
• 3. The cerebral cortex in Huntington´s disease
• 4. Degeneration of select motor and limbic nuclei of the thalamus in Huntington’s disease
• 5. Consistent and widespread degeneration of the cerebellum in Huntington’s disease
• 6. Elucidation of the role of the premotor oculomotor brainstem nuclei in the pathogenesis of oculomotor dysfunctions in Huntington’s disease
• 7. Widespread brainstem neurodegeneration in Huntington’s disease
• 8. Intraneuronal transport and defense mechanisms with possible pathogenetic relevance in Huntington’s disease
• 9. The disease protein huntingtin and neuronal protein aggregations in Huntington’s disease
• 10. Pathological nerve cell alterations in Huntington’s disease (HD) and their possible role for the demise of nerve cells
• 11. Conclusions and outlook.