The Smoothened Receptor in Cancer and Regenerative Medicine

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Ruat, Martial (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Σειρά: Topics in Medicinal Chemistry, 16
• Θέματα: Chemistry.; Cancer research.; Medicinal chemistry.; Proteins.; Medicinal Chemistry.; Receptors.; Cancer Research.

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence...

Πίνακας περιεχομένων:

• Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins
• Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators
• Receptor modifications in Hedgehog regulation
• Smoothened, stem cell maintenance and brain diseases
• Medulloblastoma, pediatric brain tumors and Smoothened blockade
• Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization
• Implications in stem cell maintenance
• Comparison of the crystal structure of Smoothened to known GPCRs structure.