The Smoothened Receptor in Cancer and Regenerative Medicine

• Corporate Author: SpringerLink (Online service)
• Other Authors: Ruat, Martial (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Series: Topics in Medicinal Chemistry, 16
• Subjects: Chemistry.; Cancer research.; Medicinal chemistry.; Proteins.; Medicinal Chemistry.; Receptors.; Cancer Research.

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence...

Table of Contents:

• Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins
• Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators
• Receptor modifications in Hedgehog regulation
• Smoothened, stem cell maintenance and brain diseases
• Medulloblastoma, pediatric brain tumors and Smoothened blockade
• Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization
• Implications in stem cell maintenance
• Comparison of the crystal structure of Smoothened to known GPCRs structure.