Chromosomal Translocations and Genome Rearrangements in Cancer

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Rowley, Janet D. (Επιμελητής έκδοσης), Le Beau, Michelle M. (Επιμελητής έκδοσης), Rabbitts, Terence H. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Έκδοση: 1st ed. 2015.
• Θέματα: Medicine.; Cancer research.; Human genetics.; Molecular biology.; Cell biology.; Biomedicine.; Cancer Research.; Cell Biology.; Human Genetics.; Molecular Medicine.

This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a...

Πίνακας περιεχομένων:

• Part I Introduction
• A short history of chromosome rearrangements and gene fusions in cancer
• Part II General
• Molecular genetics methods in discovery of chromosome structure
• Mechanism of recurrent chromosomal translocations
• Chromosome translocations, cancer initiation and clonal evolution.-  Chromosomal fragile sites and cancer
• Copy number changes in carcinomas: applications
• Part III LEUKAEMIA/LYMPHOMA
• Chronic myeloid leukaemia
• Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis
• Genetic alterations in B cell lymphoma
• Chromosomal translocations and gene rearrangements in acute lymphoblastic leukaemia
• Cellular and molecular basis of MLL leukaemias: from transformation mechanisms to novel therapeutic strategies
• Acute promyelocytic leukaemia:  from a specific translocation to cure by targeted therapies
• Chromosome Abnormalities in AML and their clinical importance
• PART IV SARCOMAS
• Fusion Oncogenes of Sarcomas
• Translocations in Ewing Sarcoma
• PART V EPITHELIAL TUMOURS
• RET and thyroid carcinomas
• Gene fusions in prostate cancer
• Chromosomal Translocations in Lung Cancer
• Colon & Ovarian translocations
• PART VI OTHER ASPECTS
• Pre-clinical modeling of chromosomal translocations and inversions
• Protein complex hierarchy & translocation gene products
• Aberrant transcriptional programming in blood cancers
• Index.