Computational Modelling of the Human Islet Amyloid Polypeptide

• Main Author: Skeby, Katrine Kirkeby (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Chemistry.; Chemoinformatics.; Bioorganic chemistry.; Medicinal chemistry.; Medicinal Chemistry.; Computer Applications in Chemistry.; Bioorganic Chemistry.

This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own...

Table of Contents:

• Amyloid and Amyloid Fibrils
• Computational Theory
• Imaging Agent Binding to Amyloid Protofibrils
• Determining the Aggregation Prone Structure of hiAPP
• Effect of Terminal Capping on Aggregation of Peptide Fragments
• Coarse Grained Study of Amyloid Protofibril Aggregation
• Conclusion and Perspectives.