Intrinsically Disordered Proteins Studied by NMR Spectroscopy

• Corporate Author: SpringerLink (Online service)
• Other Authors: Felli, Isabella C. (Editor), Pierattelli, Roberta (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Edition: 1st ed. 2015.
• Series: Advances in Experimental Medicine and Biology, 870
• Subjects: Life sciences.; Proteins.; Bioinformatics.; Cell biology.; Life Sciences.; Protein Science.; Cell Biology.

This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defin...

Table of Contents:

• Nuclear Magnetic Resonance and Bioinformatics Studies on Intrinsically Disordered Proteins
• Structure and Dynamics of Intrinsically Disordered Proteins
• NMR methods for the study of IDP structure, dynamics and interactions: general overview and practical guidelines
• Ensemble Calculation for IDPs Using NMR Parameters
• NMR Spectroscopic Studies of the Conformational Ensembles of Intrinsically Disordered Proteins
• Recombinant IDPs for NMR: Tips and Tricks
• Biophysical Methods to Investigate Intrinsically Disordered Proteins: Avoiding an “Elephant and Blind Men” Situation
• Application of SAXS for the Structural Characterization of IDPs
• Bioinformatics Approaches for Predicting Disordered Protein Motifs
• Towards Understanding Protein Disorder In-Cell
• The Protein Ensemble Database
• Order and Disorder in the Replicative Complex of Paramyxoviruses
• Druggability of Intrinsically Disordered Proteins
• Beta Amyloid Hallmarks: From Intrinsically Disordered Proteins to Alzheimer's Disease.