Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones

• Main Author: Doran, Robert (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Chemistry.; Organic chemistry.; Medicinal chemistry.; Catalysis.; Organic Chemistry.; Medicinal Chemistry.

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural pro...

Table of Contents:

• Introduction to the Total Synthesis of Lactone-Containing Natural Products using ZrCl4
• Asymmetric Synthesis of the β-Methyl-Substituted Analogues of (+)-Tanikolide and (–)-Malyngolide
• Asymmetric Synthesis of Both Enantiomers of a d-Lactone Analogue of Muricatacin
• Introduction to the Development of a Catalytic Asymmetric Synthesis of Tertiary α-Aryl Ketones
• A Stereoselective Switch: Enantiodivergent Approach to the Synthesis of Isoflavanones
• Asymmetric Synthesis of Tertiary α-Aryl Ketones by Decarboxylative Asymmetric Protonation.