Developments in T Cell Based Cancer Immunotherapies

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Ascierto, Paolo A. (Επιμελητής έκδοσης), Stroncek, David F. (Επιμελητής έκδοσης), Wang, Ena (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Humana Press, 2015.
• Έκδοση: 1st ed. 2015.
• Σειρά: Cancer Drug Discovery and Development,
• Θέματα: Medicine.; Cancer research.; Immunology.; Molecular biology.; Cell biology.; Biomedicine.; Cancer Research.; Molecular Medicine.; Cell Biology.

This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects...

Πίνακας περιεχομένων:

• 1 New insight of peptide vaccination in cancer immunotherapy
• 2 The determinants of T cell function for effective anticancer vaccine
• 3 T cell fate in the tumor microenvironment
• 4 T cell receptor avidity and affinity and tumor specific TCR engineer
• 5 Host genetic variation and somatic alteration associated with favorable or compromised T cell function
• 6 Production of Clinical T Cell Therapies
• 7 Clinical success of adoptive cell transfer therapy using tumor infiltrating lymphocytes.-8 Harnessing stem cell-like memory T cells for adoptive cell transfer therapy of cancer
• 9 T cell blockade- anti-CTLA4 immunotherapy against cancer and Abscopal effect in combination therapy
• 10 T cell modulation- anti-OD-1 antibodies for the treatment of cancer
• 11 T cell based therapies in combination with other procedures
• 12 Chimeric antigen receptor T cells CD19 CAR
• 13 Hematopoietic Stem Cell transplantation as immune therapy of malignancies.