Sample Size Determination in Clinical Trials with Multiple Endpoints

• Main Authors: Sozu, Takashi (Author), Sugimoto, Tomoyuki (Author), Hamasaki, Toshimitsu (Author), Evans, Scott R. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Edition: 1st ed. 2015.
• Series: SpringerBriefs in Statistics,
• Subjects: Statistics.; Biostatistics.; Statistical Theory and Methods.; Statistics for Life Sciences, Medicine, Health Sciences.

This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area. The determination of sample size and the...

Table of Contents:

• 1.Introduction
• 2.Continuous Co-primary Endpoints
• 3.Binary Co-primary Endpoints
• 4.Convenient Sample Size Formula
• 5.Continuous Primary Endpoints
• 6. Further Developments
• A.Sample Size Calculation Using other Contrasts for Binary Endpoints
• B.Empirical Power for Sample Size Calculation for Binary Co-primary Endpoints
• C.Numerical Tables for Ck in the Convenient Sample Size Formula for the Three Co-primary Continuous Endpoints Cace
• D.Software Programs for Sample Size Calculation for Continuous Co-primary Endpoints
• References.