Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Le Tourneau, Christophe (Επιμελητής έκδοσης), Kamal, Maud (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Έκδοση: 1st ed. 2015.
• Θέματα: Medicine.; Cancer research.; Molecular biology.; Oncology.; Pathology.; Medicine & Public Health.; Cancer Research.; Molecular Medicine.

This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques,...

Πίνακας περιεχομένων:

• Introduction: Rationale for Precision Medicine Clinical Trials.-  The Key Role of Pathology in the Context of Precision Medicine Trials
• Basis for Molecular Genetics in Cancer
• Microarrays Based Molecular Profiling to Identify Genomic Alterations
• High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential
• Bioinformatics for Precision Medicine in Oncology
• Assessment of Biomarkers’ Predictive Value of Efficacy
• Designs for Evaluating Precision Medicine Trials
• Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials.