Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering

• Κύριος συγγραφέας: Akabori, Kiyotaka (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Σειρά: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Θέματα: Physics.; Physical chemistry.; Cell membranes.; Crystallography.; Membranes (Biology) > Mechanical properties.; Membranes.; Membrane Biology.; Physical Chemistry.

This Thesis in biological physics has two components, describing the use of X-ray scattering techniques to study the structure of two different stacked lipid membrane systems.  The first part focuses on the interaction between a short 11-mer peptide, Tat, which is part of the Tat protein in the HIV-...

Πίνακας περιεχομένων:

• Introduction
• Lipid bilayers
• Tat peptide
• Pb¢ ripple phase
• Structural and Material Perturbations of Lipid Bilayers Due to HIV-1 Tat Peptide
• Introduction
• Materials and Methods
• Analysis of Molecular Dynamics Simulation Data
• Results
• Discussion
• Conclusions
• Ripple Phase
• Introduction
• Materials and Methods
• LAXS Data Reduction
• Results for Fhk Form Factors
• Models to Fit the Fhk and Obtain the Phase Factors
• Electron Density Profiles and Coarse Grained Bilayer Structure
• nGIWAXS: Results
• tWAXS: Results
• Thin Rod Model
• Combining WAXS and LAXS Results for the Major Arm
• Discussion
• Conclusion
• Appendices.