Alpha-1 Antitrypsin Role in Health and Disease /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Wanner, Adam (Editor), Sandhaus, Robert A. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Humana Press, 2016.
• Edition: 1st ed. 2016.
• Series: Respiratory Medicine,
• Subjects: Medicine.; Respiratory organs > Diseases.; Medicine & Public Health.; Pneumology/Respiratory System.

This book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children. While it is a rare condition, the mechanisms underlying its clinical manifestations have been largely clarified. Specific...

Table of Contents:

• Alpha-1- Antitrypsin and the Serpins
• Alpha-1 Antitrypsin: The protein
• Misfolding and Polymerisation of Alpha1-Antitrypsin – Conformational Pathology and Therapeutic Targeting
• Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency
• United States Targeted Detection Program for Alpha-1 Antitrypsin Deficiency
• Lung Disease of Alpha-1 Antitrypsin Deficiency
• Alpha-1-Antitrypsin Deficiency: Role in Health and Disease
• Alpha-1 Antitrypsin as a Therapeutic Agents for Conditions not Associated with Alpha-1 Antitrypsin Deficiency
• The Alpha-1 Constellation of Voluntary Health Organizations as a Paradigm for Confronting Other Rare Diseases.