Organic Cation Transporters Integration of Physiology, Pathology, and Pharmacology /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Ciarimboli, Giuliano (Επιμελητής έκδοσης), Gautron, Sophie (Επιμελητής έκδοσης), Schlatter, Eberhard (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Έκδοση: 1st ed. 2016.
• Θέματα: Medicine.; Human physiology.; Pharmacology.; Pathology.; Biomedicine.; Human Physiology.; Pharmacology/Toxicology.

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as bindi...

Πίνακας περιεχομένων:

• Introduction to the cellular transport of organic cations
• Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism
• Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity
• Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy
• Physiological and pathological regulation of transporters for organic cations
• Endocrine and metabolic regulation of transporters for organic cations
• Organic cation transporters (OCTs) as modulators of behavior and mood
• Organic cation transporters as modulators of neurodegeneration and neuroprotection
• Translational relevance of animal models for the study of organic cation transporter function
• Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues.