Quasispecies: From Theory to Experimental Systems

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Domingo, Esteban (Επιμελητής έκδοσης), Schuster, Peter (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Έκδοση: 1st ed. 2016.
• Σειρά: Current Topics in Microbiology and Immunology, 392
• Θέματα: Medicine.; Human genetics.; Immunology.; Virology.; Biomedicine.; Human Genetics.

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antivir...

Πίνακας περιεχομένων:

• What is a quasispecies?- Historical origins and current scope
• The nucleation of semantic information in prebiotic matter
• Evolution of RNA-based networks
• Quasispecies on fitness landscapes
• Mathematical models of quasispecies theory and exact results for the dynamics
• Theoretical Models of Generalized Quasispecies
• Theories of lethal mutagenesis: from error catastrophe to lethal defection
• Estimating fitness of viral quasispecies from next-generation sequencing data
• Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models
• Cooperative Interaction within RNA Virus Mutant Spectra
• Arenavirus Quasispecies And Their Biological Implications
• Models of viral population dynamics
• Fidelity variants and RNA quasispecies
• Antiviral strategies based on lethal mutagenesis and error threshold.