The Initiation of DNA Replication in Eukaryotes

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Kaplan, Daniel L. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Έκδοση: 1st ed. 2016.
• Θέματα: Medicine.; Human genetics.; Systems biology.; Microbial genetics.; Microbial genomics.; Biomedicine.; Human Genetics.; Systems Biology.; Microbial Genetics and Genomics.

Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells.  The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occ...

Πίνακας περιεχομένων:

• 1. Introduction to DNA replication initiation in eukaryotes
• 2. Choice of origins and replication timing control in yeast
• 3.  Replication timing and initiation in metazoans.- 4.  Replication timing gradients and origin activation
• 5. Genome wide localization of replication initiation factors
• 6. Genome scale analysis of metaozoan replication origins
• 7. Role of dormant origins in replication initiation
• 8. Centromeres and DNA replication initiation
• 9. Rif1 regulation of replication timing
• 10. Role of ORC in replication initiation.- 11.  Licensing of replication origins- loading Mcm2-7
• 12.  Role of chromatin in replication initiation
• 13. Role of Mcm2-7 in replication initiation
• 14. Role of CDK in replication initiation
• 15. Role of DDK in replication initiation
• 16. Roles of Sld2, Sld3, and Dpb11 in replication initiation
• 17. Role of Mcm10 in replication initiation
• 18. Role of post-translational modifications in replication initiation
• 19. Assembly of the Cdc45-Mcm2-7-GINS complex, the replication helicase.- 20. Activity of the Cdc45-Mcm2-7-GINS complex, the replication helicase
• 21. Structure function studies of replication initiation factors
• 22. Pol-alpha activation and coupling with helicase unwinding
• 23. Replication initiation and DNA damage
• 24. Protein phosphatases and replication initiation
• 25. Spindle checkpoints and replication initiation.- 26. Protein degradation and replication initiation
• 27. Break-induced replication.- 27. Meier Gorlin syndrome
• 28. Replication Stress and Cancer.