The Hsp60 Chaperonin

• Main Author: Bross, Peter (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Series: SpringerBriefs in Molecular Science,
• Subjects: Life sciences.; Molecular biology.; Bioorganic chemistry.; Proteins.; Life Sciences.; Protein Science.; Bioorganic Chemistry.; Molecular Medicine.

In this unique overview of the Hsp60 chaperonin, Peter Bross addresses molecular biologists, medical research scientists and individuals interested in molecular or general biology. First, Bross discusses the basics of the Hsp60 chaperonin in terms of its structure and the molecular mechanisms determ...

Table of Contents:

• Introduction
• Historical sketch of the discovery and recognition of the function of chaperonins
• Molecular structure of chaperonins
• Folding by enclosure in the chaperonin cavity
• Evolutionary origins and family relations
• Chaperoning mechanisms: folding helpers, folding protectors or misfolding blockers?
• Sequence variations in proteins affecting chaperonin dependence
• Genetic organization of type I chaperonin genes
• Regulation of type I chaperonin gene expression
• Subcellular localization
• Posttranslational modifications
• Variations in Hsp60 and Hsp10 in humans
• Type I chaperonins are essential for cell viability and mutations cause deficiency phenotypes
• Human diseases caused by genetic mutations in the Hsp60/Hsp10 system
• Molecular investigations of disease mechanisms
• Molecular investigations of disease mechanisms
• Outlook.