B Cell Receptor Signaling

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Kurosaki, Tomohiro (Επιμελητής έκδοσης), Wienands, Jürgen (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Έκδοση: 1st ed. 2016.
• Σειρά: Current Topics in Microbiology and Immunology, 393
• Θέματα: Medicine.; Cancer research.; Immunology.; Molecular biology.; Biomedicine.; Molecular Medicine.; Cancer Research.

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions foc...

Πίνακας περιεχομένων:

• Assembly and function of the precursor B-cell receptor
• Receptor Dissociation and B cell activation
• Molecular mechanisms of B cell antigen gathering and endocytosis
• BTK signaling in B cell differentiation and autoimmunity
• The memory function of the B cell antigen receptor
• PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL)
• Role of Calcium Signaling in B Cell Activation and Biolog
• Roles of the NF-kappaB pathway in B-lymphocyte biology
• MAP kinase cascades in antigen receptor signaling and physiology.