B Cell Receptor Signaling

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kurosaki, Tomohiro (Editor), Wienands, Jürgen (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Edition: 1st ed. 2016.
• Series: Current Topics in Microbiology and Immunology, 393
• Subjects: Medicine.; Cancer research.; Immunology.; Molecular biology.; Biomedicine.; Molecular Medicine.; Cancer Research.

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions foc...

Table of Contents:

• Assembly and function of the precursor B-cell receptor
• Receptor Dissociation and B cell activation
• Molecular mechanisms of B cell antigen gathering and endocytosis
• BTK signaling in B cell differentiation and autoimmunity
• The memory function of the B cell antigen receptor
• PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL)
• Role of Calcium Signaling in B Cell Activation and Biolog
• Roles of the NF-kappaB pathway in B-lymphocyte biology
• MAP kinase cascades in antigen receptor signaling and physiology.