Clinical Trials of Antidepressants How Changing the Model Can Uncover New, More Effective Molecules /

• Κύριος συγγραφέας: Katz, Martin M. (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Έκδοση: 1st ed. 2016.
• Σειρά: SpringerBriefs in Psychology,
• Θέματα: Psychology.; Health psychology.; Health Psychology.

This brief guide takes current clinical trial protocols to task and replaces them with a contemporary framework for improving next-generation antidepressants and their underlying science. Innovative models are based on a nuanced, neurologically-informed understanding of drug mechanisms and the compo...

Πίνακας περιεχομένων:

• Introduction
• Why Now the Need for a New Clinical Trial Model for Antidepressants?
• Reconceptualizing Depression and the Componential-Specific Model of Clinical Trials
• Aims and Basic requirements of Clinical Trials: Conventional and Component-Specific Models
• Methods for Measuring the Components and Profile of Drug Actions: The Multivantaged Approach
• The Component-Specific Model Applied in a Clinical Trial: An Example
• Comparing the Component-Specific Model Directly with the Established Diagnosis-Specific Trial
• Prediction and Shortening the Clinical Trial: Further Advantages of the Component-Specific Model
• The Video Clinical Trial and the VIBES Method
• Conclusions.