Myeloid-Derived Suppressor Cells and Cancer

• Main Authors: Escors, David (Author), Talmadge, James E. (Author), Breckpot, Karine (Author), Van Ginderachter, Jo A. (Author), Kochan, Grazyna (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Edition: 1st ed. 2016.
• Series: SpringerBriefs in Immunology,
• Subjects: Medicine.; Cancer research.; Immunology.; Oncology.; Cell biology.; Biomedicine.; Cancer Research.; Cell Biology.

The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelop...

Table of Contents:

• Controversies in Neoplastic Myeloplasia
• Differentiation of Murine Myeloid-derived Suppressor Cells
• Human MDSCs
• Ex Vivo MDSC Differentiation Models
• Immunoregulatory myeloid cells in the tumor microenvironment
• Signal Transducer and Activation of Transcription 3: A Master Regulator of Myeloid-derived Suppressor Cells
• Future Perspectives.