Control and Prediction of Solid-State of Pharmaceuticals Experimental and Computational Approaches /

• Κύριος συγγραφέας: Bhardwaj, Rajni Miglani (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Έκδοση: 1st ed. 2016.
• Σειρά: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Θέματα: Chemistry.; Pharmaceutical technology.; Physical chemistry.; Chemistry, Physical and theoretical.; Physical Chemistry.; Pharmaceutical Sciences/Technology.; Theoretical and Computational Chemistry.

This thesis investigates a range of experimental and computational approaches to the discovery of solid forms. It illustrates an inexpensive, practical and accurate way to predict the crystallizability of organic compounds based on molecular structure alone, while also highlighting the molecular fac...

Πίνακας περιεχομένων:

• Introduction
• Aims and Objectives
• Materials and Methods
• Development and Validation of High_Throughput Crystallization and Analysis (HTCAA) Methodology for Physical Form Screening
• Predicting Crystallizability of Organic Molecules using Statistical Modelling Techniques
• Exploring Crystal Structure Landscape of Olanzapine
• Exploring the Physical Form Landscape of Clozapine, Amoxapine and Loxapine
• Conclusions and Further Work.