New Approaches to Drug Discovery

• Corporate Author: SpringerLink (Online service)
• Other Authors: Nielsch, Ulrich (Editor), Fuhrmann, Ulrike (Editor), Jaroch, Stefan (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Edition: 1st ed. 2016.
• Series: Handbook of Experimental Pharmacology, 232
• Subjects: Medicine.; Pharmacology.; Medical biochemistry.; Pharmacy.; Metabolism.; Biomedicine.; Pharmacology/Toxicology.; Drug Safety and Pharmacovigilance.; Medical Biochemistry.; Metabolomics.

This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different par...

Table of Contents:

• Preface
• Part 1. Historical View
• Drug discovery in the past and today.Part 2. Target Discovery
• Emerging target families: intractable targets. In vivo target validation especially for biological targets. HR RNAi/High Content analysis
• Part 3. Lead generation and Optimization
• Sources for leads: natural products, libraries. Screening: assays, readout, technology. Impact of structural biology, fragment based screening/Virtual screening. Predictive in silico tools of compound properties. High throughput synthesis. New compound classes: Protein-Protein Interaction. Sources for biological leads/Screening of biologicals
• Part 4. Test systems for Efficacy and Safety
• In vitro / Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact of biomarkers/personalized medicine. Simulating in vivo drug effects.