Physics at the Biomolecular Interface Fundamentals for Molecular Targeted Therapy /

• Κύριος συγγραφέας: Fernández, Ariel (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Σειρά: Soft and Biological Matter,
• Θέματα: Physics.; Molecular biology.; Pharmaceutical technology.; Physical chemistry.; Proteins.; Biophysics.; Biological physics.; Statistical physics.; Dynamical systems.; Biophysics and Biological Physics.; Physical Chemistry.; Pharmaceutical Sciences/Technology.; Protein Structure.; Molecular Medicine.; Statistical Physics, Dynamical Systems and Complexity.

This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophy...

Πίνακας περιεχομένων:

• Chapter 1 Interfacial Physics for Water in Biology
• Chapter 2 Dielectric Structure of Aqueous Interfaces: From Classical non-Debye Electrostatics to a Quantum Theory of Interfacial Tension
• Chapter 3 Solution to the Protein Folding Problem
• Chapter 4 Epistructural Dynamics of Biological Water
• Chapter 5 Dehydron-Rich Proteins in the Order-Disorder Twilight Zone
• Chapter 6 Dehydron as a Marker for Molecular Evolution: Lessons for the Drug Designer
• Chapter 7 Catalytic Role of Dehydrons in Soluble Proteins: Biological Chemistry of Frustrated Interfacial Water
• Chapter 8 Epistructural Selectivity Filters for Molecular Targeted Therapy
• Chapter 9 Epistructural Re-Engineering ofImatinib to Eliminate Adverse Side Effects
• Chapter 10 Epistructural Informatics for the Drug Designer
• Chapter 11 Drug-Target Associations Inducing Protein Folding
• Chapter 12 Combination Therapies to Edit Out Side Effects and Resistance to Inhibition of Drug Resistance
• Chapter 13 Epistructure-Based Design of Drugs with Controlled Promiscuity
• Chapter 14 Synergizing Engineered Immunotherapy with Molecularly Targeted Cancer Treatment
• Chapter 15 Quantum Mechanical Concepts for Epistructural Drug Design
• Chapter 16 Structure-Based Drug Discovery Without Structure: Working Around the Paradox to Disrupt Protein-Protein Associations
• Chapter 17 Epistructural Drug Design to Treat Cancer Metastasis and the Associated Drug Resistance.