Group Sequential and Confirmatory Adaptive Designs in Clinical Trials
This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under contr...
Κύριοι συγγραφείς: | , |
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Συγγραφή απο Οργανισμό/Αρχή: | |
Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
Γλώσσα: | English |
Έκδοση: |
Cham :
Springer International Publishing : Imprint: Springer,
2016.
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Σειρά: | Springer Series in Pharmaceutical Statistics,
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Θέματα: | |
Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Part I Group Sequential Designs
- Repeated Significance Tests: Procedures with Equally Sized Stages
- Procedures with Unequally Sized Stages
- Confidence Intervals, p -Values, and Point Estimation
- Applications
- Part II Adaptive Confirmatory Designs with a Single Hypothesis: Adaptive Group Sequential Tests
- Decision Tools for Adaptive Designs
- Estimation and p-Values for Two-stage Adaptive Designs
- Adaptive Designs with Survival Data
- Part III Adaptive Designs with Multiple Hypotheses: Multiple Testing in Adaptive Designs
- Applications and Case Studies
- Appendix - Software for Adaptive Designs
- Index.