Validation of Alternative Methods for Toxicity Testing

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Eskes, Chantra (Επιμελητής έκδοσης), Whelan, Maurice (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Σειρά: Advances in Experimental Medicine and Biology, 856
• Θέματα: Medicine.; Molecular biology.; Pharmaceutical technology.; Biomedicine.; Pharmaceutical Sciences/Technology.; Molecular Medicine.

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Πίνακας περιεχομένων:

• Introduction
• Validation in support of internationally harmonised OECD Test Guidelines for assessing the safety of chemicals
• Regulatory acceptance of alternative methods in the development and approval of pharmaceuticals
• Validation of alternative in vitro methods to animal testing: concepts, challenges, processes and tools
• Practical aspects of designing and conducting validation studies involving multi-study trials
• Validation of computational methods
• Implementation of New Test Methods into Practical Testing
• Pathway Based Toxicology and Fit-for-Purpose Assays
• Evidence-based toxicology
• Validation of transcriptomics-based in vitro methods
• Ensuring the quality of stem cell-derived in vitro models for toxicity testing
• Validation of bioreactor and human-on-a-chip devices for chemical safety assessment
• Integrated approaches to testing and assessment
• International harmonization and cooperation in the validation of alternative methods
• Evolving the principles and practice of validation for new alternative approaches to toxicity testing. .