Modified Nucleic Acids in Biology and Medicine

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Jurga, Stefan (Επιμελητής έκδοσης), Erdmann (Deceased), Volker A. (Επιμελητής έκδοσης), Barciszewski, Jan (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Σειρά: RNA Technologies,
• Θέματα: Medicine.; Human genetics.; Molecular biology.; Biotechnology.; Nucleic acids.; Biomedicine.; Human Genetics.; Nucleic Acid Chemistry.; Molecular Medicine.

This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily m...

Πίνακας περιεχομένων:

• Transfer RNA Modifications: from Biological Functions to Biomedical Applications
• Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications
• Sulfur-Modifications in tRNA: Function and Implications for Human Disease
• Regulation of Protein Synthesis via the Network Between Modified Nucleotides in tRNA and tRNA Modification Enzymes in Thermus thermophilus, Athermophilic Eubacterium
• Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health
• RNA Modification N6-methyladenosine in Post-Transcriptional Regulation
• 8-Hydroxyguanine, an Oxidative DNA and RNA Modification
• Methods for Determination of 2’-O-Me in RNA
• DiadenosineTetraphosphate (Ap4A), in Health and Disease
• Thinking Small: Circulating MicroRNAs as Novel Biomarkers for Diagnosis, Prognosis and Treatment Monitoring in Breast Cancer
• Modified Antisense Oligonucleotides and their Analogs in Therapy of Neuromuscular Diseases
• Effect of Depurination on Cellular and Viral RNA
• Recognition of RNA Sequence and Structure by Duplex and Triplex Formation: Targeting miRNA and pre-miRNA
• Modifications in Therapeutic Oligonucleotides Improving the Delivery
• Interstrand Cross-Linking of Nucleic Acids: from History Towards Recent and Future Applications
• Chemical Synthesis of Lesion-Containing Oligonucleotides for DNA-Repair Studies
• Single-Molecule Visualization of Biomolecules in the Designed DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy
• Polymerase Reactions that Involve Modified Nucleotides.