PI3K-mTOR in Cancer and Cancer Therapy

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Dey, Nandini (Επιμελητής έκδοσης), De, Pradip (Επιμελητής έκδοσης), Leyland-Jones, Brian (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Humana Press, 2016.
• Σειρά: Cancer Drug Discovery and Development,
• Θέματα: Medicine.; Cancer research.; Drug resistance.; Molecular biology.; Biomedicine.; Cancer Research.; Molecular Medicine.; Drug Resistance.

In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhe...

Πίνακας περιεχομένων:

• PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics
• Part 1: PI3K-mTOR Pathway in Cancers
• The mTOR Complexes in Cancer Cell Metabolism
• PI3K-AKT-mTOR Pathway Co-operates with the DNA Damage Repair Pathway: Carcinogenesis in Triple Negative Breast Cancers and Beyond
• The AKT-mTOR Signaling Pathway for Drug Response Prediction and Prognostic Signatures
• Resistance to PI3K Pathway Inhibition
• Part 2: PI3K-mTOR Pathway in Cancer Medicine
• Combination Therapies Targeting the PI3K/AKT/mTOR Pathways
• Phospho-Inositol-3-Kinase Activity and Dysregulation in Pediatric Leukemia and Lymphoma
• HER2 Signaling Network in Advanced Breast Cancer: Opportunities for Combination Therapies
• The PI3K-mTOR Pathway in Prostate Cancer: Biological Significance and Therapeutic Opportunities.