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02933nam a22004815i 4500 |
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978-3-319-38878-6 |
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|a 9783319388786
|9 978-3-319-38878-6
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|a 10.1007/978-3-319-38878-6
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|a 547.05
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|a McDonald, Stacey L.
|e author.
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|a Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds
|h [electronic resource] /
|c by Stacey L. McDonald.
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2016.
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|a XXIII, 144 p. 8 illus.
|b online resource.
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|a text
|b txt
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|a computer
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|b PDF
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|a Springer Theses, Recognizing Outstanding Ph.D. Research,
|x 2190-5053
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|a Electrophilic amination for the synthesis of alkyl and aryl amines -- Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates -- Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives -- Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C−H Zincation.
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|a This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. .
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|a Chemistry.
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|a Organometallic chemistry.
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|a Chemical engineering.
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|a Medicinal chemistry.
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|a Chemistry.
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|a Organometallic Chemistry.
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|a Medicinal Chemistry.
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|a Industrial Chemistry/Chemical Engineering.
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9783319388779
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|a Springer Theses, Recognizing Outstanding Ph.D. Research,
|x 2190-5053
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|u http://dx.doi.org/10.1007/978-3-319-38878-6
|z Full Text via HEAL-Link
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|a ZDB-2-CMS
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|a Chemistry and Materials Science (Springer-11644)
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