Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules

• Κύριος συγγραφέας: Sharpe, Robert.J (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Σειρά: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Θέματα: Chemistry.; Organic chemistry.; Chemical engineering.; Medicinal chemistry.; Organic Chemistry.; Medicinal Chemistry.; Industrial Chemistry/Chemical Engineering.

This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction st...

Πίνακας περιεχομένων:

• Asymmetric Synthesis Of The Aminocyclitol Pactamycin, A Universal Translocation Inhibitor
• Preparation And Biological Evaluation Of Synthetic and Polymer-Encapsulated Congeners of the Antitumor Agent Pactamycin: Insight Into Functional Group Effects and Biological Activity
• Inception and Development of a Global and Local Desymmetrization Approach to the Synthesis of Steroidal Alkaloids: Stereocontrolled Total Synthesis of Paspaline.