Pharmacokinetics in Drug Development Problems and Challenges in Oncology, Volume 4 /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Bonate, Peter L. (Επιμελητής έκδοσης), Howard, Danny R. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Θέματα: Medicine.; Pharmaceutical technology.; Oncology.; Biomathematics.; Biomedicine.; Pharmaceutical Sciences/Technology.; Mathematical and Computational Biology.

Back cover copy In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies. This book delivers, with an emphasis on the oncology therapeutic...

Πίνακας περιεχομένων:

• Overview of Oncology Drug Development
• A Global Perspective on First-In-Man Dose Selection: Oncology and Beyond
• Controversies in Oncology: Size-Based vs. Fixed Dosing
• Clinical QTc Assessment in Oncology
• Expediting Drug Development: Breakthrough Therapy Designation
• Pharmacokinetics and Pharmacodynamics of Tyrosine Kinase Inhibitors
• Combination Development
• Role of Pharmacokinetics-Pharmacodynamics in Biosimilar Assessments
• Pharmacokinetics and Pharmacogenetics of Metronomics
• Modeling Tumor Growth in Animals and Humans: an Evolutionary Approach
• Practical Considerations for Clinical Pharmacology in Oncology Drug Development: A Survey of Approvals from 2009-2015
• New Advancements in Exposure-Response Analysis to Inform Regulatory Decision-Making .