Nanoscale Imaging and Characterisation of Amyloid-β

• Main Author: Tinker-Mill, Claire Louisa (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Physics.; Molecular biology.; Neurology.; Amorphous substances.; Complex fluids.; Spectroscopy.; Microscopy.; Nanotechnology.; Spectroscopy and Microscopy.; Soft and Granular Matter, Complex Fluids and Microfluidics.; Molecular Medicine.

This thesis presents a method for reliably and robustly producing samples of amyloid-β (Aβ) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting i...

Table of Contents:

• Introduction
• Literature Review and Theoretical Concepts
• Experimental Methodology
• Substrate Development of the Imaging of Amyloid Proteins with SPM Methods
• Scanning Probe Microscopy Methods of Imaging Amyloid Peptides During the Aggregation Process
• Spectroscopy and Thermal SPM Methods of Studying Aβ1:42
• The Application of Biophysical Techniques to the Study of the Inhibition of Aggregation of Aβ Using PINPs Liposomes
• Conclusion and Future Perspectives.