Increasing the Therapeutic Ratio of Radiotherapy

• Corporate Author: SpringerLink (Online service)
• Other Authors: Tofilon, Philip J. (Editor), Camphausen, Kevin (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Humana Press, 2017.
• Series: Cancer Drug Discovery and Development,
• Subjects: Medicine.; Cancer research.; Drug resistance.; Radiotherapy.; Biomedicine.; Cancer Research.; Drug Resistance.

Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal t...

Table of Contents:

• Part 1. Molecular Targets
• 1. Improving the therapeutic ratio of radiotherapy by targeting the DNA Damage Response
• 2. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity
• 3. Histone Deacetylase Inhibitors and Tumor Radiosensitization
• 4. Radioprotection as a Method to Enhance the Therapeutic Ratio of Radiotherapy
• Part 2. Microenvironment
• 5. Application of Functional Molecular Imaging in Radiation Oncology
• 6. Remodeling the Irradiated Tumor Microenvironment: The 5th R of Radiobiology?
• 7. Combining Radiotherapy and Immunotherapy: Emerging Preclinical Observations of Lymphocyte Costimulatory and Inhibitory Receptor Modulation
• Part 3. Clinical
• 8. Stereotactic Body Radiation Therapy (SBRT) or Alternative Fractionation Schedules
• 9. Novel Imaging for Treatment Planning or Tumor Response
• 10. Increasing the Therapeutic Efficacy of Radiotherapy Using Nanoparticles
• Index.