Melanoma Development Molecular Biology, Genetics and Clinical Application /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Bosserhoff, Anja K. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Edition: 2nd ed. 2017.
• Subjects: Medicine.; Cancer research.; Biomedicine.; Cancer Research.

This book focuses on malignant melanoma, discussing the current state of scientific knowledge and providing insights into the underlying basic mechanisms, the molecular changes, genetics and genomics. Human Melanoma is a dangerous type of skin cancer affecting an increasing population, and a better...

Table of Contents:

• Clinicopathologic Overview of Melanoma
• Revisiting Epidermal Melanocytes: Regulation of Their Survival, Proliferation, and Function in Human Skin
• Melanoma Epidemiology
• Melanoma Genetics and Genomics
• Transcriptional Regulation in Melanoma
• MiRNAs in Malignant Melanoma
• Altered Signal Transduction Pathways in Melanoma
• Proteases in Melanoma
• Cell-cell contacts in melanoma and the tumor microenvironment
• Regulation of Apoptosis in Melanoma Cells: Critical Targets for Therapeutic Strategies
• Senescence
• Melanoma Stem Cells
• The Birth of Malignancy: Embryogenesis and Melanoma
• Tumor Microenvironment for Melanoma Cells
• Melanoma Model Systems
• New Approaches to Signaling
• Immune checkpoint inhibitors in melanoma define a new area in immunotherapy aiming for cure. .