Systems Biology of Tumor Microenvironment Quantitative Modeling and Simulations /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Rejniak, Katarzyna A. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Series: Advances in Experimental Medicine and Biology, 936
• Subjects: Medicine.; Cancer research.; Biomathematics.; Biomedicine.; Cancer Research.; Mathematical and Computational Biology.; Biological and Medical Physics, Biophysics.

This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics cove...

Table of Contents:

• Foreword
• Preface
• List of Contributors
• Image Analysis of the Tumor Microenvironment
• Hypoxia in Gliomas: Opening Therapeutical Opportunities Using a Mathematical-Based Approach
• Computer Simulations of the Tumor Vasculature: Applications to Interstitial Fluid Flow, Drug Delivery, and Oxygen
• Cell-ECM Interactions in Tumor Invasion
• Circulating Tumor Cells: When Solid tumor Meets Fluid Microenvironment
• Modeling Proteolytically Driven Tumor Lymphangiogenesis
• Positive feedback loops between inflammatory, bone and cancer cells during metastatic niche construction
• Microenvironmental Niches and Sanctuaries: a Route to Acquired Resistance
• The Tumor Microenvironment as a Barrier to Cancer Nanotherapy
• Microenvironment-Mediated Modeling of Tumor Response to Vascular-Targeting Drugs
• Optimizing Chemotherapeutic Anti-Cancer Treatment and the Tumor Microenvironment: An Analysis of Mathematical Models
• Progress towards computational 3-D multicellular systems biology
• Index.