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03280nam a22004815i 4500 |
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|a 9783319422237
|9 978-3-319-42223-7
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|a 10.1007/978-3-319-42223-7
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|a MED062000
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|a Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
|h [electronic resource] /
|c edited by Emmanuel Donnadieu.
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2016.
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|a VIII, 199 p. 27 illus., 19 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
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|a text file
|b PDF
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|a Resistance to Targeted Anti-Cancer Therapeutics,
|x 2196-5501 ;
|v 9
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|a Introduction -- Basic rules of T cell migration -- Regulation of anti-tumor T cell migration and function: contribution of real-time imaging -- Vascular normalization, T cell trafficking and anti-tumor immunity -- Disruption of anti-tumor T cell responses by cancer-associated fibroblasts -- Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic -- Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy -- Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors -- Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumors.
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|a This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.
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| 650 |
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|a Medicine.
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| 650 |
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|a Cancer research.
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| 650 |
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|a Immunology.
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| 650 |
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|a Molecular biology.
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| 650 |
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|a Biomedicine.
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| 650 |
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|a Cancer Research.
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| 650 |
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|a Immunology.
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| 650 |
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|a Molecular Medicine.
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| 700 |
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|a Donnadieu, Emmanuel.
|e editor.
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| 710 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9783319422213
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| 830 |
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|a Resistance to Targeted Anti-Cancer Therapeutics,
|x 2196-5501 ;
|v 9
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| 856 |
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|u http://dx.doi.org/10.1007/978-3-319-42223-7
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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