Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Donnadieu, Emmanuel (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Σειρά: Resistance to Targeted Anti-Cancer Therapeutics, 9
• Θέματα: Medicine.; Cancer research.; Immunology.; Molecular biology.; Biomedicine.; Cancer Research.; Molecular Medicine.

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these t...

Πίνακας περιεχομένων:

• Introduction
• Basic rules of T cell migration
• Regulation of anti-tumor T cell migration and function: contribution of real-time imaging
• Vascular normalization, T cell trafficking and anti-tumor immunity
• Disruption of anti-tumor T cell responses by cancer-associated fibroblasts
• Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic
• Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy
• Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors
• Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumors.