|
|
|
|
| LEADER |
03768nam a22004815i 4500 |
| 001 |
978-3-319-42609-9 |
| 003 |
DE-He213 |
| 005 |
20161216102322.0 |
| 007 |
cr nn 008mamaa |
| 008 |
161216s2016 gw | s |||| 0|eng d |
| 020 |
|
|
|a 9783319426099
|9 978-3-319-42609-9
|
| 024 |
7 |
|
|a 10.1007/978-3-319-42609-9
|2 doi
|
| 040 |
|
|
|d GrThAP
|
| 050 |
|
4 |
|a RS380
|
| 050 |
|
4 |
|a RS190-210
|
| 072 |
|
7 |
|a TDCW
|2 bicssc
|
| 072 |
|
7 |
|a MED072000
|2 bisacsh
|
| 082 |
0 |
4 |
|a 615.19
|2 23
|
| 245 |
1 |
0 |
|a Formulating Poorly Water Soluble Drugs
|h [electronic resource] /
|c edited by Robert O. Williams III, Alan B. Watts, Dave A. Miller.
|
| 250 |
|
|
|a 2nd ed. 2016.
|
| 264 |
|
1 |
|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2016.
|
| 300 |
|
|
|a XIV, 779 p. 210 illus., 84 illus. in color.
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 347 |
|
|
|a text file
|b PDF
|2 rda
|
| 490 |
1 |
|
|a AAPS Advances in the Pharmaceutical Sciences Series,
|x 2210-7371 ;
|v 22
|
| 505 |
0 |
|
|a Route-Specific Challenges in Delivery of Poorly Water Soluble Drugs -- Optimizing the Formulation of Poorly Water Soluble Drugs -- Solid-State Techniques for Improving Solubility -- Mechanical Particle Size Reduction Techniques -- Solubilized Formulations -- Injectable Formulations of Poorly Water Soluble Drugs -- Design and Development of Self-Emulsifying Lipid Formulations for Improving Oral Bioavailability of Poorly Water-Soluble and Lipophilic Drugs -- Structured Development Approach for Amorphous Systems -- Melt Extrusion -- Spray Drying Technology -- Pharmaceutical Cryogenic Technologies -- Precipitation Technologies for Nanoparticle Production -- Emerging Technologies to Increase the Bioavailability of Poorly Water Soluble Drugs -- Regulatory Considerations for Development and Commercialization of Poorly Water Soluble Drugs.
|
| 520 |
|
|
|a The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.
|
| 650 |
|
0 |
|a Medicine.
|
| 650 |
|
0 |
|a Pharmaceutical technology.
|
| 650 |
1 |
4 |
|a Biomedicine.
|
| 650 |
2 |
4 |
|a Pharmaceutical Sciences/Technology.
|
| 700 |
1 |
|
|a Williams III, Robert O.
|e editor.
|
| 700 |
1 |
|
|a Watts, Alan B.
|e editor.
|
| 700 |
1 |
|
|a Miller, Dave A.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 776 |
0 |
8 |
|i Printed edition:
|z 9783319426075
|
| 830 |
|
0 |
|a AAPS Advances in the Pharmaceutical Sciences Series,
|x 2210-7371 ;
|v 22
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1007/978-3-319-42609-9
|z Full Text via HEAL-Link
|
| 912 |
|
|
|a ZDB-2-SBL
|
| 950 |
|
|
|a Biomedical and Life Sciences (Springer-11642)
|
