Immunotherapy for Gastrointestinal Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kerr, David (Editor), Johnson, Rebecca (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Subjects: Medicine.; Immunology.; Gastroenterology.; Oncology.; Medicine & Public Health.

This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clini...

Table of Contents:

• Introduction to modern immunology
• Cell based therapy – modified cancer cells
• Vaccines for GI cancer
• Antibody delivery of radioactive ‘warheads’ and cytotoxins
• Antibodies which inhibit specific cell pathways
• PD1 and PD1l immune checkpoint inhibitors
• The Role of the JAK/STAT Signaling Pathway in Immunoregulation of Gastrointestinal Cancers
• Hyper mutated colorectal cancer and neoantigen load
• Antibodies which inhibit specific cell pathways, colorectal cancer.