The Ageing Immune System and Health

• Corporate Author: SpringerLink (Online service)
• Other Authors: Bueno, Valquiria (Editor), Lord, Janet M. (Editor), Jackson, Thomas A. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Subjects: Medicine.; Immunology.; Geriatrics.; Cell biology.; Aging.; Medicine & Public Health.; Geriatrics/Gerontology.; Cell Biology.

The present book intends to provide an update on immunosenescence and how deficiencies in the immune system contribute to a higher susceptibility to infections, decline in organ function, reduced vaccination responses, age-related disease and the ageing process itself, negatively affecting longevity...

Table of Contents:

• 1. Introduction
• 2. Innate Immune Response and Ageing (neutrophils, monocytes, dendritic cells, DAMPs, PAMPs
• 3. Adaptive Immune Response and Aging (T and B lymphocytes, naïve, effector and memory phenotypes and functions)
• 4. Modulatory/Suppressive Cells and Ageing (T regulatory cells, B regulatory cells, Myeloid Derived Suppressor Cells, Modulatory Neutrophils, M1 and M2 macrophages)
• 5. Mucosal Immune System and Ageing
• 6. Epigenetics and Ageing
• 7. Cancer and Ageing
• 8. Infections/Vaccination and Ageing
• 9. Cytomegalovirus and immmunosenescence
• 10. Frailty and Ageing
• 11. Inflammation and Neurodegenerative Diseases and Ageing
• 12. Effects of chronic inflammatory diseases (chronic kidney disease, rheumatoid arthritis, crohns disease etc) on the ageing of the immune system
• 13. Interventions in Elderly focusing Immunosenescence (physical activity, nutrition, supplements).