Imaging Biomarkers Development and Clinical Integration /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Martí-Bonmatí, Luis (Επιμελητής έκδοσης), Alberich-Bayarri, Angel (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Θέματα: Medicine.; Radiology.; Biomedical engineering.; Medicine & Public Health.; Imaging / Radiology.; Biomedical Engineering.

This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification inst...

Πίνακας περιεχομένων:

• The shift in paradigm to precision medicine in imaging
• International initiatives for the promotion of imaging biomarkers
• Introduction to the stepwise development of imaging biomarkers
• Defining the biological basis and clinical question: proof of concept
• Looking for the inter-relationship: proof of mechanism
• Images acquisition: modality and protocol definition
• Images preparation
• Imaging biomarkers analysis
• Imaging biomarkers measurements
• Detecting measurement biases: the proof of principle
• Validating the imaging biomarker: the proof of efficacy and effectiveness
• The final step: Reporting imaging biomarkers results
• Sources of uncertainty: accuracy and precision of the measurements
• Pearls and pitfalls in Gold standards and biological correlation
• Imaging biobanks, big data and population-based imaging biomarkers
• A proposed Imaging Biomarkers analysis platform architecture for integration in clinics
• Use case I: Imaging biomarkers in neurodegenerative disease
• Use case II: Imaging biomarkers in tumors
• Use case III: Imaging biomarkers in thorax and heart
• Use case IV: Imaging biomarkers in musculoskeletal disorders
• Use case V: Imaging biomarkers in diffuse liver disease.