Systems Pharmacology and Pharmacodynamics

While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This boo...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Mager, Donald E. (Επιμελητής έκδοσης), Kimko, Holly H.C (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
Σειρά:AAPS Advances in the Pharmaceutical Sciences Series, 23
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • Role of Systems Modeling in Regulatory Drug Approval
  • Quantitative Systems Pharmacology: Applications and Adoption in Drug Development
  • Systems Pharmacology: An Overview
  • Discrete dynamic modeling: a network approach for systems pharmacology
  • Kinetic Models of Biochemical Signaling Networks
  • Mechanistic Models of Physiological Control Systems
  • Foundations of Pharmacodynamic Systems Analysis
  • Direct, Indirect, and Signal Transduction Response Modeling
  • Irreversible Pharmacodynamics
  • Feedback Control Indirect Response Models
  • Nonlinear Mixed Effects Modeling in Systems Pharmacology
  • Detecting Pharmacokinetic and Pharmacodynamic Covariates From High-Dimensional Data
  • Multi-Scale Modeling of Drug Action in the Nervous System
  • Mechanistic Modeling of Inflammation
  • Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities
  • Translational Modeling of Antibacterial Agents
  • Viral Dynamic Modeling of Hepatitis C Virus Infection: Past Successes and Future Challenges
  • Using Systems Pharmacology to Advance Oncology Drug Development
  • Systems Pharmacology Modeling in Type 2 Diabetes Mellitus.