The Glutamate/GABA-Glutamine Cycle Amino Acid Neurotransmitter Homeostasis /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Schousboe, Arne (Επιμελητής έκδοσης), Sonnewald, Ursula (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Σειρά: Advances in Neurobiology, 13
• Θέματα: Medicine.; Neurosciences.; Biomedicine.

Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “Th...

Πίνακας περιεχομένων:

• Introduction to the Glutamate-Glutamine cycle
• Glucose, lactate, β-hydroxybutyrate, acetate, GABA, and succinate as substrates for synthesis of glutamate and GABA in the glutamine-glutamate/GABA cycle
• Anaplerosis for glutamate synthesis in the neonate and in adulthood
• Enzyme complexes important for the glutamate-glutamine cycle
• BCAA metabolism and NH3 homeostasis
• Glutaminases Vesicular Glutamate Uptake
• The glutamine transporters and their role in the Glutamate/GABA-Glutamine Cycle
• Glutamine Metabolism in Gliomas
• Oligodendrocytes: development, physiology and glucose metabolism
• Dysregulation of glutamate cycling mediates methylmercury-induced neurotoxicity
• Astroglia, glutamatergic transmission and psychiatric diseases
• Glutamine Synthetase: Role in Neurological Disorders
• The Glutamate – Glutamine Cycle in Epilepsy
• Index.