Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition

• Main Author: Velmurugu, Yogambigai (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Physics.; Proteins.; Spectroscopy.; Microscopy.; Biological and Medical Physics, Biophysics.; Spectroscopy and Microscopy.; Protein-Ligand Interactions.

Using a novel approach that combines high temporal resolution of the laser T-jump technique with unique sets of fluorescent probes, this study unveils previously unresolved DNA dynamics during search and recognition by an architectural DNA bending protein and two DNA damage recognition proteins. Man...

Table of Contents:

• Introduction
• Methods
• Integration Host Factor (IHF)-DNA interaction
• Lesion Recognition by Xeroderma Pigmentosum C (XPC) Protein
• DNA Mismatch Repair.