The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease Cushing’s Syndrome and Beyond /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Geer, Eliza B. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Θέματα: Medicine.; Endocrinology.; Systems biology.; Medicine & Public Health.; Systems Biology.

Cushing´s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the...

Πίνακας περιεχομένων:

• Part 1. Hypothalamic-pituitary-adrenal axis regulation of the body, brain, and inflammation
• 1. Glucocorticoid regulation of body composition and metabolism
• 2. Glucocorticoid regulation of neurocognitive and neuropsychiatric function
• 3. Glucocorticoids: Inflammation and Immunity
• Part 2. Cushing’s Syndrome
• 4. Pathogenesis, diagnosis and localization of Cushing’s: Molecular pathogenesis of primary adrenal Cushing’s syndrome
• . 5. Pathogenesis, diagnosis and localization of Cushing’s
• 5. Pathogenesis, diagnosis and localization of Cushing’s: Pathogenesis and treatment of aggressive corticotroph pituitary tumors - Yang Shen and Anthony P Heaney
• 6. Pathogenesis, diagnosis and localization of Cushing’s: Neoplastic/Pathologic and Non-neoplastic/Physiologic Hypercortisolism: Cushing verses Pseudo-Cushing Syndromes
• 7. Pathogenesis, diagnosis and localization of Cushing’s: Imaging strategies for localization of ACTH - secreting tumors
• 8. Recent Advances in the medical and surgical treatment of Cushing’s: Surgical Treatment of Cushing’s disease
• 9. Recent Advances in the medical and surgical treatment of Cushing’s: Medical therapies in Cushing’s syndrome
• 10. New themes in Cushing’s definitions and outcomes: Mild adrenal cortisol excess – 11. New themes in Cushing’s definitions and outcomes: Long term effects of prior Cushing’s syndrome
• 12. New themes in Cushing’s definitions and outcomes: Cushing’s disease: refining the definition of remission and recurrence
• Part 3. Beyond Cushing’s: Glucocorticoid sensitivity, regulation and the metabolic syndrome
• 13. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis through a Mutated Glucocorticoid Receptor
• 14. Cortisol metabolism as a regulator of the tissue-specific glucocorticoid action
• 15. Obesity and metabolic syndrome: a phenotype of mild long-term hypercortisolism.