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03084nam a22004815i 4500 |
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978-3-319-46240-0 |
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DE-He213 |
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20161108132343.0 |
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cr nn 008mamaa |
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161108s2016 gw | s |||| 0|eng d |
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|a 9783319462400
|9 978-3-319-46240-0
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|a 10.1007/978-3-319-46240-0
|2 doi
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|a QD431-431.7
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|a SCI007000
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|a 572.6
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|a Capillary Electrophoresis-Mass Spectrometry
|h [electronic resource] :
|b Therapeutic Protein Characterization /
|c edited by James Q. Xia, Lichao Zhang.
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2016.
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| 300 |
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|a IX, 74 p. 28 illus., 21 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
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|a text file
|b PDF
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|a Introduction to Capillary Electrophoresis—Mass Spectrometry -- Coated Capillaries for CE-MS of Therapeutic Protein -- Intact Mass Analysis of Monoclonal Antibodies by Capillary Electrophoresis–Mass Spectrometry -- Separation and Characterization of Proteins and Peptides in Biological Fluids using CE-MS -- Host Cell Protein Analysis using CE-MS -- Antibody PTM Analysis using CE-MS -- Characterization of Intact Therapeutic Proteins and Protein Subunits using CE-MS Platform.
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|a This book covers the latest developments in capillary electrophoresis-mass spectrometry for the analysis of therapeutic proteins. The application of capillary electrophoresis-mass spectrometry (CE-MS) coupling technology in the analysis of recombinant therapeutic proteins is detailed thoroughly. Specific topics include recent developments in coupling capillary electrophoresis with mass spectrometry for the quality control of monoclonal antibody therapeutics, top-down analysis of monoclonal antibody using the CE-MS platform, and detection of host cell protein impurities. Comprehensive characterization of antibody-drug conjugates (ADCs) by coupling capillary electrophoresis with mass spectrometry is also covered. This is an ideal book for scientists in the life science and biopharmaceutical industry who are working on characterizing the PTMs of monoclonal antibodies, as well as graduate students and researchers in the separation science and biological mass spectrometry fields.
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| 650 |
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|a Life sciences.
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| 650 |
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|a Mass spectrometry.
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| 650 |
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|a Proteins.
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| 650 |
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|a Spectroscopy.
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| 650 |
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|a Microscopy.
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| 650 |
1 |
4 |
|a Life Sciences.
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| 650 |
2 |
4 |
|a Protein Science.
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| 650 |
2 |
4 |
|a Mass Spectrometry.
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| 650 |
2 |
4 |
|a Spectroscopy and Microscopy.
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| 700 |
1 |
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|a Xia, James Q.
|e editor.
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| 700 |
1 |
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|a Zhang, Lichao.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9783319462387
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/978-3-319-46240-0
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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