Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

• Corporate Author: SpringerLink (Online service)
• Other Authors: Grawunder, Ulf (Editor), Barth, Stefan (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: Milestones in Drug Therapy,
• Subjects: Medicine.; Cancer research.; Antibodies.; Pharmacology.; Oncology.; Pharmacotherapy.; Biomedicine.; Pharmacology/Toxicology.; Cancer Research.

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introd...

Table of Contents:

• Chemical Assembly of Antibody-Drug Conjugates
• Pre-clinical evaluation of ADCs delivering highly potent pyrrolobenzodiazepine (PBD) dimers
• Stable and homogeneous drug conjugation by sequential bis-alkylation at disulfide bonds using bis-sulfone reagents
• Calicheamicin antibody-drug conjugates for liquid- and solid tumor indications
• Enzyme-based strategies to generate site-specifically conjugated Antibody Drug Conjugates
• Substance P – Saporin for the Treatment of Intractable Pain
• Recombinant immunotoxins for Chronic Inflammatory Disease
• BL22: A milestone in targeting CD22.