Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Grawunder, Ulf (Επιμελητής έκδοσης), Barth, Stefan (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Σειρά: Milestones in Drug Therapy,
• Θέματα: Medicine.; Cancer research.; Antibodies.; Pharmacology.; Oncology.; Pharmacotherapy.; Biomedicine.; Pharmacology/Toxicology.; Cancer Research.

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introd...

Πίνακας περιεχομένων:

• Chemical Assembly of Antibody-Drug Conjugates
• Pre-clinical evaluation of ADCs delivering highly potent pyrrolobenzodiazepine (PBD) dimers
• Stable and homogeneous drug conjugation by sequential bis-alkylation at disulfide bonds using bis-sulfone reagents
• Calicheamicin antibody-drug conjugates for liquid- and solid tumor indications
• Enzyme-based strategies to generate site-specifically conjugated Antibody Drug Conjugates
• Substance P – Saporin for the Treatment of Intractable Pain
• Recombinant immunotoxins for Chronic Inflammatory Disease
• BL22: A milestone in targeting CD22.