Immunopathology in Toxicology and Drug Development Volume 1, Immunobiology, Investigative Techniques, and Special Studies /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Parker, George A. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Humana Press, 2017.
• Series: Molecular and Integrative Toxicology,
• Subjects: Medicine.; Immunology.; Pharmaceutical technology.; Medical biochemistry.; Pathology.; Medicine & Public Health.; Pharmaceutical Sciences/Technology.; Medical Biochemistry.

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assa...

Table of Contents:

• Basic Immunobiology
• Cells of the Immune System
• Signaling and effector molecules in immunity
• Development of immune system organs
• Aging of immune system organs
• Flow cytometry and immunophenotyping in drug development
• Pathology evaluation for detection of immunomodulation
• Enhanced immunohistopathology
• Clinical Pathology Assays in Immunopathology
• Application of immunohistochemistry in toxicologic pathology of the hematolymphoid system
• Morphometry and stereology in immunopathology
• Molecular techniques in immunopathology
• Current issues in developmental immunotoxicity
• The Murine local lymph node assay
• Host Resistance assays for efficacy and immunotoxicology safety evaluations. .