Human Retrotransposons in Health and Disease

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Cristofari, Gael (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Θέματα: Medicine.; Human genetics.; Stem cells.; Microbial genetics.; Microbial genomics.; Biomedicine.; Human Genetics.; Microbial Genetics and Genomics.; Stem Cells.

This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-med...

Πίνακας περιεχομένων:

• Retrotransposons and the Mammalian Germline
• L1 regulation in Mouse and Human Germ Cells
• Retrotransposon Contribution to Genomic Plasticity
• The Mobilization of Processed Transcripts in Germline and Somatic Tissues
• Neuronal Genome Plasticity: Retrotransposons, Environment and Disease
• Activity of Retrotransposons in Stem Cells and Differentiated Cells
• Environment, Cellular Signaling and L1 activity
• Retrotransposon-derived Regulatory Regions and Transcripts in Stemness
• Roles of Endogenous Retrovirus-encoded Syncytins in Human Placentation
• Alu-Alu Recombinations in Genetic Diseases
• Retrotransposon-driven Transcription and Cancer
• LINE-1 retrotransposons as Neoplastic Biomarkers
• Contribution of Retrotransposable Elements to Aging.