Leucine-Rich Repeat Kinase 2 (LRRK2)

• Corporate Author: SpringerLink (Online service)
• Other Authors: Rideout, Hardy J. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: Advances in Neurobiology, 14
• Subjects: Medicine.; Neurosciences.; Neurology.; Biomedicine.
• Physical Description: XVII, 271 p. 27 illus., 17 illus. in color. online resource.
• ISBN: 9783319499697
• ISSN: 2190-5215 ;

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.