Translational Anatomy and Cell Biology of Autism Spectrum Disorder

• Corporate Author: SpringerLink (Online service)
• Other Authors: Schmeisser, Michael J. (Editor), Boeckers, Tobias M. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: Advances in Anatomy, Embryology and Cell Biology, 224
• Subjects: Medicine.; Neurosciences.; Psychiatry.; Cell biology.; Biomedicine.; Cell Biology.

Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying cau...

Table of Contents:

• Anatomy and cell biology of autism spectrum disorder: Lessons from human genetics
• Neuroanatomy and neuropathology of autism spectrum disorder in humans
• Modelling autistic neurons with induced pluripotent stem cells
• Modelling autistic features in mice using quantitative genetic approaches
• Behavioural phenotypes and neural circuit dysfunctions in mouse models of autism spectrum disorder
• Cerebellar and striatal pathologies in mouse models of autism spectrum disorder
• The role of neurotrophic factors in mouse models of autism spectrum disorder: focus on Bdnf and Igf-1
• The role of the oxytocin/arginine vasopressin system in animal models of autism spectrum disorder
• Extracerebral dysfunction in animal models of autism spectrum disorder
• Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder.