Computational Methods for Processing and Analysis of Biological Pathways

• Main Authors: Bezerianos, Anastasios (Author), Dragomir, Andrei (Author), Balomenos, Panos (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: SpringerBriefs in Computer Science,
• Subjects: Computer science.; Bioinformatics.; Systems biology.; Computer Science.; Computational Biology/Bioinformatics.; Systems Biology.

 This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways. 

 Introduction -- Networks and Pathways in Systems Pharmacology -- Time Varying Methods for Pathway and Sub-Pathway Analysis -- Identification of Differentially Expressed Pathways and Sub-Pathways.